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First Survivor

The Impossible Childhood Cancer Breakthrough

First Survivor: The Impossible Childhood Cancer Breakthrough
It Is Illuminating and tender and educational and wins our hearts.
- Grady H.
“This is one of those books that has the power to encourage you not to give up no matter the struggles you might be facing in life.”
- Kathy H.
"I think this book is a best seller in the true sense of the word, sensitively written; providing hope and strength to those who read and understand that “there are no dead ends, only new paths”.
- Winston P.

This is a real life thriller about a family’s battle to save their son from a “zero chance of survival” diagnosis.

With the world’s best doctors and the advocacy of his parents, Louis Unger would fight the battle for his young life. At age 3, Louis was diagnosed with stage 4 neuroblastoma. He battled this treacherous cancer for 5 years with the leadership of the neuroblastoma team at Memorial Sloan Kettering. After relapsing with the cancer in his brain, his incredible team of doctors developed a new treatment protocol that cured him. His grit and incredible attitude led to a breakthrough that would change how cancer is treated today. This protocol is now helping to save many other children who are diagnosed with a brain relapse. 

From the Book

"When he walked into his office that morning, the first thing he saw was Louis, low in vitality, resting on the examination table. Dr. Germain dropped the folder of X-rays he was carrying. A mishap from an organized man might well indicate a sense of disturbance, and Gregory Germain’s momentary and uncharacteristic clumsiness did speak volumes—he had dreadful news to share. The blood tests taken at the same time as the recent X-rays were showing what he called—for the moment “extreme anemia,” meaning low blood counts, low energy, and a lack of oxygen that would produce lethargy. With kindness and urgency, he insisted we go to the Children’s Emergency Room at Yale-New Haven Hospital, where he would meet us immediately. My wife and I looked at each other and then we both looked at Louis in total silence."

Louis Unger’s Neuroblastoma Survivor Story

"Naturally, I had to Google the word nadir in the context of this strange world of chemo. It turns out that adults in chemotherapy hit the nadir within ten days after their initial treatment. Adults are typically given a break before the second dosage to allow the cells to rebuild. Normal service, as it were, is resumed in twenty to thirty days in an adult body. A child’s metabolism is different. Often, shorter timespans prevail—both in reaching the nadir and rising from it. Why, then, might anyone—why might Louis Unger—need a bone marrow transplant?”

A breakthrough that changed how childhood cancer is treated today.

"While Mary Ellen was spending time with Lou at the hospital and I was at home with Harry we talked on the phone about somehow getting the boys together. Suddenly, I was inspired with a crazy plan. I said, “Okay, we’re driving to Yale, I’m going to put Harry in a suitcase, and I’m just going to wheel the suitcase in, right? Nobody’s going to know. I’m going to wheel the suitcase into Lou’s room, and put it down. And then, when I pop it open Lou’s going to be surprised” Finally, some fun!

Harry remembers it well: “Oh, we walked in with the suitcase. We went up to an empty floor, unzipped the case and I got in the fetal position and crawled in. He zipped me up, pressed the button—I remember him talking with the doctors, there are like doctors in the elevator and we were really nonchalant and we got out. He rolls me in the room, opens up the case, and Louis is so happy. He was fantastic!”

Louis Unger | Childhood Cancer Survivor | Neuroblastoma

"I had a bad feeling when we drove the twenty minutes to Yale. Mary Ellen was worried, of course, but Louis was being tested for cancer, full battery of scans, bloodwork, biopsy once a month so I wasn’t expecting the brain tumor, how would that not have shown up in the testing?

Now we stared at each other again and our thoughts instantly crossed—this is bad, very bad. My mind was racing.

The roller-coaster had crashed. Our trap door opened and I was falling hard. Louis had relapsed. Not just a “normal” relapse but a brain tumor. It was the most feared of all neuroblastoma relapses. What are the chances of survival? This time we knew. We’d done our homework. We’d heard the doctor in Chicago. The fact was that no child had ever survived a neuroblastoma relapse presenting as a brain tumor. In other words, the chances were zero.”

Louis Unger survived a neuroblastoma relapse presenting as a brain tumor.

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Mark Unger, the author of this book, is the father of Louis Unger, the boy who was able to survive cancer despite all the medical evidence that suggested otherwise. Fortunately, I haven’t had to deal with cancer personally yet, but I think it’s important that people are aware of the disease and approaches of treating it. That being said, I found it impossible not to relate to little Lou’s and his parents’ struggles, and I find this book could be a true source of hope and inspiration for people whose family members are affected by cancer. “First Survivor” is not a medical book, and it’s not a book that promises to give you the ultimate cancer cure or survival recipe. And yet it is empowering because it shows you that hope is never lost and you can (and should) fight for your life even if it seems like the one thing you can do is give up. I also enjoyed the glossary and the reference sections at the end to explain some of the medical concepts.

Stephen R. Wilson
Amazon Reader

First Survivor is an inspirational story about little Louis Unger who fought with everything he had, despite his very young age, to live. Louis was diagnosed with neuroblastoma, which is a type of brain cancer, at the tender age of 3. At a time when children are playing, making friends and generally exploring life, Louis was exploring treatment options that would keep him alive and kill the cancer. The story follows the family's tedious and trying journey from 2001 to 2008, when he was finally cured. The book is penned by his father, Mark Unger, who says that Louis never gave up the will to beat the disease and survive. This is not a self-help book or anything of that sort. It is simply a story. A story that aims to inspire and be a source of support for all those parents whose children are suffering from the same deadly disease that Louis did.

Priyanka Athavale
Amazon reader

A striking and emotional read for anyone. I will admit that as a mother of three young children, I had a really hard time getting through this book. I just wanted to cry with the parents. While the situation that the entire Unger family went through is horrible, this book is definitely worth the read. The author, Mark Unger, does a wonderful job with keeping the information understandable and easy to follow along with what was going to happen. He does a wonderful job with details in this book and you really feel for their story. As hard as it was for me to emotionally get through this book I found that I also had a hard time putting it down. I just had to know that everything would work out at the end. This book is a fantastic book for all parents to read as a reminder that they are there to protect their children in all situations.

Kim B
Amazon Reader

"Mary Ellen and Mark Unger are parent advocates like I had never seen before or since. Negotiating the complicated world of Pediatric Oncology, the varied clinicians, the medical terminology, multiple medical centers, experimental protocols, and the emotional ups and downs of advanced parenting must have seemed impossible. But the Ungers, not medically trained when they started this journey, took on the challenge and were incredibly effective. Eventually, I think, saving their son's life. Mary Ellen and Mark stand as role models for all parents who advocate for their kids. And they have shown me that effective advocacy is not only important for every parent, but it is possible in any situation. Even the most dire."

Gregory Germain
MD, Pediatrician

"So very many aspects of Louis’ story stand out incomparably – and so vividly highlight the virtuous side of the human condition and predicament. Some of us might be most moved and inspired by Louis’ parents, with their love, devotion, dedication, fortitude, self-sacrifice. Nothing is more precious than an innocent child – or more tragic, difficult to confront, and beyond human understanding than when a young one is stricken by a lethal malady that causes pain and suffering. So how wonderful it is that Louis has now grown up to be a thriving and vibrant young man! And how amazing it is that every one of the untold number of killer cancer cells that had permeated his entire body could be eradicated. Kudos to the multi-varied treatment program that included powerful chemotherapy, targeted immunotherapy, as well as the then novel and experimental attack against relapse in the brain - all developed at MSK."

Brian Kushner
MD, Pediatric Oncologist, Memorial Sloan Kettering Cancer Center

“It was difficult to believe the tides would change when Louis was unfairly handed a lethal diagnosis, one that resulted in death for all too many innocent children. To be a part of Louis’ journey is a privilege I hold dear to my heart… to hold his shining smile up to the children that come after him is a gift unparalleled. As a reader of Louis’ story, you too can embrace him, and all that his story represents…”

Kim Kramer
MD, Pediatric Oncologist, Memorial Sloan Kettering Cancer Center

"This book chronicles the suffering, despair, and ultimate triumph of the Unger family in overcoming a deadly pediatric cancer called neuroblastoma. Faced with desperate situations, his loving family was determined to save his young life by reaching out to friends and the internet to search for expertise in novel cancer therapies. Throughout this arduous journey, and without any guarantee of success, they have courageously walked into the unknown. Louis was indeed a trail blazer in the then untested clinical study, which has now proven to help many other children afflicted with neuroblastoma that has spread to the brain. We all salute the Ungers for their courage."

Nai-Kong V. Cheung
MD, PhD, Head, Neuroblastoma Program; Enid A. Haupt Chair in Pediatric Oncology, Memorial Sloan Kettering Cancer Center

About the Author

Mark Unger, Author, First Survivor: The Impossible Childhood Cancer Breakthrough

Our son’s battle with childhood cancer changed everything for my family. Sharing our story brings all the difficult emotions flooding back, but I believe it's a journey worth describing because it might help others. This book shows how my family cried, laughed, and rode the scariest roller coaster imaginable.   Our son’s survival became an obsession. We learned it was ultimately up to us to protect our son and to find the best path for his survival. Louis, who was three when first diagnosed, showed the unrelenting courage and determination of a true warrior. He gave us the strength to confront and reject the diagnosis of “Zero chance of survival.”  

I hope this book honors our extended family, friends, and the dedicated doctors who ultimately made the difference between life and death for our son. My message is this: There are no dead ends, only new paths.

Ask the Author

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Help Support Childhood Cancer Research

All proceeds from this book will go to the Carrot Seed Foundation. Mark and his wife started this foundation to help find a cure for neuroblastoma and to support the children and families who are stricken by this disease.
For more information go to

Band of Parents | Funding Childhood Cancer Research

In 2007, a group of desperate families asked the head of neuroblastoma program at Memorial Sloan Kettering, Dr. Nai-Kong Cheung, what they could do to help their children.  He said there was a severe lack of funding for research and that better treatments are on the horizon, but could only come to fruition with more research. A short time later, about 100 families of children in treatment for neuroblastoma came together to form the Band of Parents. In the past decade, it has expanded its advocacy, funding research in several major cancer centers throughout the U.S. Band of Parents has committed more than $6 million to neuroblastoma research.   For more information or to donate, please go to:

Learn About Pediatric NeuroblastomaLearn About Research Funding

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